Oral Minoxidil; Safe Dose

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Oral Minoxidil; Safe Dose

Responder to Minoxidil and Initial Hair Loss

There is a difference in individual constitution regarding the response to a drug. It is the difference between responder and non-responder.

Responder means a person in whom a drug works effectively. Non-responder means a person in whom no remarkable difference can be noticed by using a drug.

When someone starts using minoxidil for the first time for the treatment of hair loss, the person may notice increase in hair shedding after shampoo and in the daily life.

This response is what is called “minoxidil shedding” or “Rogaine shedding”, which means initial hair loss that can be observed from a few weeks to 1-2 months after the start of minoxidil treatment.

The mechanism of minoxidil shedding (initial hair loss) is discussed in details on the other page on this website.

Initial hair loss is a good sign indicating that the person is a responder to minoxidil. Hair shedding will decrease in 1-2 months, and hair thickness will increase significantly from 4-6 months to 6-12 months.

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Kuniyoshi YAGYU, MD

General Manager, Ginza HS Clinic (current position) | Director, Ginza HS Clinic (current position) | Graduated from the University of Tokyo, Medical School.
Doctor of Medicine.

The 24th President of the International Society of Hair Restoration Surgery (ISHRS), a Board of Governors of the Asian Association of Hair Restoration Surgeons (AAHRS), a Fellow of the ISHRS, and a Diplomate of the American Board of Hair Restoration Surgery (ABHRS).

He has received many awards for his outstanding achievements in hair transplantation, including “Research Award” and “Special Achievement Award” from the ISHRS, “Mediterranean Award”, “Tiberio Award” and “Caesar Award” from the Italian Society for Hair Science and Restoration, and “Hirayama Award” from the Japan Society of Clinical Hair Restoration.

He is a certified registered physician of the Japan Surgical Society, an Honorary Fellow of cardiovascular surgery of the Japanese Association for Thoracic Surgery, a Fellow of the Japanese Circulation Society, and a Fellow of the Japanese Respiratory Society.

He served as a director of cardiovascular surgery at the Japanese Red Cross Medical Center, and an Assistant Professor at the University of Tokyo, Medical School. He studied at the Hannover Medical School in the Federal Republic of Germany on a scholarship by the Alexander von Humboldt Foundation.

Kuniyoshi Yagyu, MD, FISHRS. He served as the President of the International Society of Hair Restoration Surgery from 2015 to 2016. He is a board member of the Asian Association of Hair Restoration Surgeons. He is a Diplomate of the American Board of Hair Restoration Surgery and a Winner of the ISHRS Research Award in 2010, and ISHRS Poster Award in 2014. He has authored more than 53 research and clinical publications in books and journals. He had been specialized in cardiac surgery for 22 years. He has been practicing hair transplantation for about 20 years in Tokyo, Japan.