Oral Minoxidil; Safe Dose

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Oral Minoxidil; Safe Dose

Background of Minoxidil Therapy

Cellular Regulation and Hair Cycle:

Minoxidil and other potassium channel openers work on hair follicular cells. They have effects to keep hair growth in human dermal papilla.

Minoxidil increases proliferation and DNA synthesis of follicular and perifollicular cells.

Minoxidil is effective to increase the size and length, and the number of hair follicles in the mid and late anagen phase.
Minoxidil normalizes proliferation and morphology of inner root sheath and matrix.

Minoxidil increases VEGF (vascular endothelial growth factor) in the cultured dermal papilla cells extracts.
VEGF is strongly expressed in the dermal papilla in the anagen phase. VEGF increases new blood vessels formation and development of vascular network.

In the telogen phase, VEGF decreases and most blood vessels disappear.

In this way, minoxidil plays an important role in cellular regulation and vascularization at the dermal papilla.

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Kuniyoshi YAGYU, MD

General Manager, Ginza HS Clinic (current position) | Director, Ginza HS Clinic (current position) | Graduated from the University of Tokyo, Medical School.
Doctor of Medicine.

The 24th President of the International Society of Hair Restoration Surgery (ISHRS), a Board of Governors of the Asian Association of Hair Restoration Surgeons (AAHRS), a Fellow of the ISHRS, and a Diplomate of the American Board of Hair Restoration Surgery (ABHRS).

He has received many awards for his outstanding achievements in hair transplantation, including “Research Award” and “Special Achievement Award” from the ISHRS, “Mediterranean Award”, “Tiberio Award” and “Caesar Award” from the Italian Society for Hair Science and Restoration, and “Hirayama Award” from the Japan Society of Clinical Hair Restoration.

He is a certified registered physician of the Japan Surgical Society, an Honorary Fellow of cardiovascular surgery of the Japanese Association for Thoracic Surgery, a Fellow of the Japanese Circulation Society, and a Fellow of the Japanese Respiratory Society.

He served as a director of cardiovascular surgery at the Japanese Red Cross Medical Center, and an Assistant Professor at the University of Tokyo, Medical School. He studied at the Hannover Medical School in the Federal Republic of Germany on a scholarship by the Alexander von Humboldt Foundation.

Kuniyoshi Yagyu, MD, FISHRS. He served as the President of the International Society of Hair Restoration Surgery from 2015 to 2016. He is a board member of the Asian Association of Hair Restoration Surgeons. He is a Diplomate of the American Board of Hair Restoration Surgery and a Winner of the ISHRS Research Award in 2010, and ISHRS Poster Award in 2014. He has authored more than 53 research and clinical publications in books and journals. He had been specialized in cardiac surgery for 22 years. He has been practicing hair transplantation for about 20 years in Tokyo, Japan.