Oral Minoxidil; Safe Dose

Background of Minoxidil Therapy

Cellular Regulation and Hair Cycle:

Minoxidil and other potassium channel openers work on hair follicular cells. They have effects to keep hair growth in human dermal papilla.

Minoxidil increases proliferation and DNA synthesis of follicular and perifollicular cells.

Minoxidil is effective to increase the size and length, and the number of hair follicles in the mid and late anagen phase.
Minoxidil normalizes proliferation and morphology of inner root sheath and matrix.

Minoxidil increases VEGF (vascular endothelial growth factor) in the cultured dermal papilla cells extracts.
VEGF is strongly expressed in the dermal papilla in the anagen phase. VEGF increases new blood vessels formation and development of vascular network.

In the telogen phase, VEGF decreases and most blood vessels disappear.

In this way, minoxidil plays an important role in cellular regulation and vascularization at the dermal papilla.

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