Gene Analysis of Pattern Hair Loss:
PGD2 & CRTH2
Prostaglandin D2 (PGD2) binds to its receptor (CRTH2) in the hair follicles.
PGD2-receptor complex has been reported to inhibit maturation of stem cells, inducing miniaturization of hair follicles and alopecia.
CRTH2 gene encodes the PGD2 receptor. The CRTH2 is activated by PGD2.
The CRTH2 is expressed on Th2-T cells, eosinophils and basophils that mediate chemotaxis and acute inflammatory cytokine production, histamine release, and chronic allergic inflammation.
Gene Analysis of Pattern Hair Loss:
PGE2
PGD, PGF and PGE interact with PG receptors (CRTH2 and PTGFR) and regulators (PTGES2 and SULT1A1).
These interactions have been reported to affect hair loss.
Gene Analysis of Pattern Hair Loss:
PTGFR gene & PGF2alpha
PTGFR (prostanoid FP receptor) is a gene that mediates the activity of a receptor of PGF2α. Prostanoid FP receptor is expressed in the human dermal papillae.
Prostaglandin F2α (PGF2α) is medicine, which is used for the treatment of glaucoma.
Latanoprost is one of the analogs of PGF2α, which is also commonly used for the treatment of glaucoma in the clinical medicine.
One of the most well-known side effects of PGF2α is thickening and elongation of eyelashes.
Minoxidil sometimes makes eyelashes longer and thicker too.
