Basic Research on AGA (Vol. 3) Gene Analysis & Other Issues

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Basic Research on AGA (Vol. 3) Gene Analysis & Other Issues

IGF-1

Insulin-like growth factor (IGF-1) is produced by dermal papilla cells.

IGF-1 increases hair growth, and it prevents the entry of hair follicles into the catagen phase.

Growth hormone and IGF-1 decrease testosterone and DHT in the area of AGA.

IGF-1 binds to IGF-1 Receptor

IGF-1 binds to receptors on the cell surface (IGF-1R) and regulates the migration and proliferation of hair follicular cells.

It has been reported that about 40% of people have low plasma IGF-1 levels, which may be due to allele mutations in the IGF-1R gene.

Recent studies have reported that insulin resistance and hyperglycemia increase serum IGF-1 levels, induce cell proliferation, and increase the risk of cancers in the liver, kidney, pancreas, colon and stomach in patients with type II diabetes.

IGF-1 also increases active estrogen which may result in an increased risk of breast cancer and uterus cancer in women.

High blood sugar, insulin resistance and IGF-1 can also cause mitochondrial dysfunction, increase oxidative stress, impair DNA repair, and stimulate oncogenes.

Prostaglandin Metabolism

Prostaglandins (PG) are hormone-like substances made in the tissues.
There are many types of PGs that control blood pressure, body temperature, activation of inflammatory responses, contraction of smooth muscles, etc.

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Kuniyoshi YAGYU, MD

General Manager, Ginza HS Clinic (current position) | Director, Ginza HS Clinic (current position) | Graduated from the University of Tokyo, Medical School.
Doctor of Medicine.

The 24th President of the International Society of Hair Restoration Surgery (ISHRS), a Board of Governors of the Asian Association of Hair Restoration Surgeons (AAHRS), a Fellow of the ISHRS, and a Diplomate of the American Board of Hair Restoration Surgery (ABHRS).

He has received many awards for his outstanding achievements in hair transplantation, including “Research Award” and “Special Achievement Award” from the ISHRS, “Mediterranean Award”, “Tiberio Award” and “Caesar Award” from the Italian Society for Hair Science and Restoration, and “Hirayama Award” from the Japan Society of Clinical Hair Restoration.

He is a certified registered physician of the Japan Surgical Society, an Honorary Fellow of cardiovascular surgery of the Japanese Association for Thoracic Surgery, a Fellow of the Japanese Circulation Society, and a Fellow of the Japanese Respiratory Society.

He served as a director of cardiovascular surgery at the Japanese Red Cross Medical Center, and an Assistant Professor at the University of Tokyo, Medical School. He studied at the Hannover Medical School in the Federal Republic of Germany on a scholarship by the Alexander von Humboldt Foundation.

Kuniyoshi Yagyu, MD, FISHRS. He served as the President of the International Society of Hair Restoration Surgery from 2015 to 2016. He is a board member of the Asian Association of Hair Restoration Surgeons. He is a Diplomate of the American Board of Hair Restoration Surgery and a Winner of the ISHRS Research Award in 2010, and ISHRS Poster Award in 2014. He has authored more than 53 research and clinical publications in books and journals. He had been specialized in cardiac surgery for 22 years. He has been practicing hair transplantation for about 20 years in Tokyo, Japan.