Basic Research on AGA (Vol. 3) Gene Analysis & Other Issues

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Basic Research on AGA (Vol. 3) Gene Analysis & Other Issues

Insulin-like Growth Factor-1 (IGF-1)

There is a relationship between serum insulin-like growth factor-1 (IGF-1) and male pattern baldness.

IGF-1 is produced by dermal papilla cells. It is involved in hair growth.

IGF-1 and Insulin Metabolism

IGF-1 stimulates hair growth and prevents the premature entry of hair follicles into the catagen phase.

Growth hormone and IGF-1 increase hair growth and decrease testosterone and DHT in the area of male pattern baldness.

IGF-1 binds to IGF-1 Receptor

IGF-1 regulates cellular proliferation and migration during the development of hair follicles.

IGF-1 binds to cell-surface receptors (IGF1R) and exhibits biological effects.

The activity of IGF-1 receptors is encoded by the IGF1R (IGF-1 Receptor) gene. IGF1R (insulin-like growth factor 1 receptor) is a gene encoding the activity of IGF-1 receptors.

Mutations in insulin receptors tend to develop alopecia.

It has been reported that patients with mutations in insulin receptors are resistant to insulin, and they are more likely to develop alopecia.

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Kuniyoshi YAGYU, MD

General Manager, Ginza HS Clinic (current position) | Director, Ginza HS Clinic (current position) | Graduated from the University of Tokyo, Medical School.
Doctor of Medicine.

The 24th President of the International Society of Hair Restoration Surgery (ISHRS), a Board of Governors of the Asian Association of Hair Restoration Surgeons (AAHRS), a Fellow of the ISHRS, and a Diplomate of the American Board of Hair Restoration Surgery (ABHRS).

He has received many awards for his outstanding achievements in hair transplantation, including “Research Award” and “Special Achievement Award” from the ISHRS, “Mediterranean Award”, “Tiberio Award” and “Caesar Award” from the Italian Society for Hair Science and Restoration, and “Hirayama Award” from the Japan Society of Clinical Hair Restoration.

He is a certified registered physician of the Japan Surgical Society, an Honorary Fellow of cardiovascular surgery of the Japanese Association for Thoracic Surgery, a Fellow of the Japanese Circulation Society, and a Fellow of the Japanese Respiratory Society.

He served as a director of cardiovascular surgery at the Japanese Red Cross Medical Center, and an Assistant Professor at the University of Tokyo, Medical School. He studied at the Hannover Medical School in the Federal Republic of Germany on a scholarship by the Alexander von Humboldt Foundation.

Kuniyoshi Yagyu, MD, FISHRS. He served as the President of the International Society of Hair Restoration Surgery from 2015 to 2016. He is a board member of the Asian Association of Hair Restoration Surgeons. He is a Diplomate of the American Board of Hair Restoration Surgery and a Winner of the ISHRS Research Award in 2010, and ISHRS Poster Award in 2014. He has authored more than 53 research and clinical publications in books and journals. He had been specialized in cardiac surgery for 22 years. He has been practicing hair transplantation for about 20 years in Tokyo, Japan.