Basic Research on AGA (Vol. 3) Gene Analysis & Other Issues

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Basic Research on AGA (Vol. 3) Gene Analysis & Other Issues

Growth Factors and Cytokines related to Hair Loss and Hair Growth

There are many types of growth factors and cytokines related to hair loss and regrowth.

They include PDGF, Wnt-7a, VEGF, KGF, Leptin, FGF, FGF-7, βFGF, follistatin and IGF-1.

Other Growth Factors and Cytokines that increase Hair Growth

Other growth factors and cytokines that increase hair growth include EGF, HGF, FGF-9, Noggin, SOD and ATP.

Future research studies may reveal the positive and negative effects of different growth factors on hair regrowth.

Antiandrogens

Spironolactone, flutamide and 5alpha-reductase (5α-reductase) inhibitors can usually be used as androgen-receptor antagonists to block androgenic effects in the target tissues of patients with androgen overload.

Progesterone competitively inhibits the binding of DHT to the cytosol androgen receptors. It inhibits formation of 5α metabolites from androstenedione.
Progesterone is rapidly metabolized to non-androgenic substances in the skin and many other tissues.

One potent inhibitor of 5α-reductase is finasteride, which reduces androgenic effects by reducing the local synthesis of DHT in the target cells.

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Kuniyoshi YAGYU, MD

General Manager, Ginza HS Clinic (current position) | Director, Ginza HS Clinic (current position) | Graduated from the University of Tokyo, Medical School.
Doctor of Medicine.

The 24th President of the International Society of Hair Restoration Surgery (ISHRS), a Board of Governors of the Asian Association of Hair Restoration Surgeons (AAHRS), a Fellow of the ISHRS, and a Diplomate of the American Board of Hair Restoration Surgery (ABHRS).

He has received many awards for his outstanding achievements in hair transplantation, including “Research Award” and “Special Achievement Award” from the ISHRS, “Mediterranean Award”, “Tiberio Award” and “Caesar Award” from the Italian Society for Hair Science and Restoration, and “Hirayama Award” from the Japan Society of Clinical Hair Restoration.

He is a certified registered physician of the Japan Surgical Society, an Honorary Fellow of cardiovascular surgery of the Japanese Association for Thoracic Surgery, a Fellow of the Japanese Circulation Society, and a Fellow of the Japanese Respiratory Society.

He served as a director of cardiovascular surgery at the Japanese Red Cross Medical Center, and an Assistant Professor at the University of Tokyo, Medical School. He studied at the Hannover Medical School in the Federal Republic of Germany on a scholarship by the Alexander von Humboldt Foundation.

Kuniyoshi Yagyu, MD, FISHRS. He served as the President of the International Society of Hair Restoration Surgery from 2015 to 2016. He is a board member of the Asian Association of Hair Restoration Surgeons. He is a Diplomate of the American Board of Hair Restoration Surgery and a Winner of the ISHRS Research Award in 2010, and ISHRS Poster Award in 2014. He has authored more than 53 research and clinical publications in books and journals. He had been specialized in cardiac surgery for 22 years. He has been practicing hair transplantation for about 20 years in Tokyo, Japan.