Basic Research on Androgenetic Alopecia (AGA) (Vol. 2) Hair Growth Medicine & Genes

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Basic Research on Androgenetic Alopecia (AGA) (Vol. 2) Hair Growth Medicine & Genes

5α-Reductase; Type I & Type II

The optimal PH is 7.0 for type I 5 alpha-reductase (5α-reductase), and 5.5 for type II 5α-reductase.

The locus of the gene is chromosome 5 for type I 5α-reductase, and chromosome 2 for type II 5α-reductase.

Type I 5α-reductase is more widely located in the skin than type II 5α-reductase.
Type I 5α-reductase is located in the sebaceous glands and dermal papillae of the scalp hair follicles.

Type II 5α-reductase is located in the outer root sheath, inner root sheath, dermal papillae, and dermal fibroblasts.
The differences in hair growth in different regions may be related to local differences in 5α-reductase.

DHT production is increased in the balding scalp of men.
DHT is also increased in the scalp of women, but the levels are much lower than in men.

Men with type II 5α-reductase deficiency do not develop androgenetic alopecia.

What is Dihydrotestosterone (DHT)?

Dihydrotestosterone (DHT) is an active metabolite of testosterone.
Testosterone is converted to DHT by an enzyme named 5α-reductase.

DHT plays an important role in the development of alopecia in male and female AGA.

DHT is circulating in the blood. DHT is also produced in the scalp tissue.
Both locally produced DHT and circulating DHT are involved in AGA.
The level of DHT in the scalp tissue is thought to play a more important role in AGA than serum DHT.

Is DHT a good hormone or a bad hormone?

DHT is an essential hormone. DHT is necessary to maintain the physical activity and healthy body condition of the human body.

What are the good things about DHT?

DHT enhances muscle, strength, and bone growth. It promotes the development of adolescent males.

DHT promotes vitality, heart function, and memory in men and women.
DHT helps to maintain cognitive function.

DHT improves sexual function. It is necessary for sexual development.

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Kuniyoshi YAGYU, MD

General Manager, Ginza HS Clinic (current position) | Director, Ginza HS Clinic (current position) | Graduated from the University of Tokyo, Medical School.
Doctor of Medicine.

The 24th President of the International Society of Hair Restoration Surgery (ISHRS), a Board of Governors of the Asian Association of Hair Restoration Surgeons (AAHRS), a Fellow of the ISHRS, and a Diplomate of the American Board of Hair Restoration Surgery (ABHRS).

He has received many awards for his outstanding achievements in hair transplantation, including “Research Award” and “Special Achievement Award” from the ISHRS, “Mediterranean Award”, “Tiberio Award” and “Caesar Award” from the Italian Society for Hair Science and Restoration, and “Hirayama Award” from the Japan Society of Clinical Hair Restoration.

He is a certified registered physician of the Japan Surgical Society, an Honorary Fellow of cardiovascular surgery of the Japanese Association for Thoracic Surgery, a Fellow of the Japanese Circulation Society, and a Fellow of the Japanese Respiratory Society.

He served as a director of cardiovascular surgery at the Japanese Red Cross Medical Center, and an Assistant Professor at the University of Tokyo, Medical School. He studied at the Hannover Medical School in the Federal Republic of Germany on a scholarship by the Alexander von Humboldt Foundation.

Kuniyoshi Yagyu, MD, FISHRS. He served as the President of the International Society of Hair Restoration Surgery from 2015 to 2016. He is a board member of the Asian Association of Hair Restoration Surgeons. He is a Diplomate of the American Board of Hair Restoration Surgery and a Winner of the ISHRS Research Award in 2010, and ISHRS Poster Award in 2014. He has authored more than 53 research and clinical publications in books and journals. He had been specialized in cardiac surgery for 22 years. He has been practicing hair transplantation for about 20 years in Tokyo, Japan.