Basic Research on Androgenetic Alopecia (AGA) (Vol. 2) Hair Growth Medicine & Genes

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Basic Research on Androgenetic Alopecia (AGA) (Vol. 2) Hair Growth Medicine & Genes

Analysis of SRD5A2 Gene

Analysis of the SRD5A2 gene polymorphism has possibility to predict effectiveness of hair restoration therapy by androgen-deprivation with 5α-reductase inhibitors.

The results of genetic analysis may tell us about individual differences in responsiveness to each drug.

Responders and non-responders to finasteride and dutasteride may be identified by the gene analysis before the treatment of hair loss.

Gene analysis may help each patient with AGA to choose more effective hair regrowth medicine in the future.

Aromatase (Cytochrome P450 Enzyme)

Aromatase (cytochrome P450 enzyme) changes testosterone to estradiol and estrone.

Acceleration of this metabolism relatively reduces the conversion of testosterone to DHT.
A decrease in the level of DHT has a protective effect on the hair follicles.

This means that aromatase has a protective effect on the hair follicles in the androgen metabolism of AGA.

Aromatase Inhibitor

Aromatase inhibitors reduce the activity of aromatase.
A decrease in aromatase activity leads to a decrease in the conversion of testosterone to estrogen.

Then, testosterone is guided to the other pathway, which relatively increases the conversion of testosterone into DHT.

This is the reason why hair thinning can develop in women treated with aromatase inhibitors for breast cancer.

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Kuniyoshi YAGYU, MD

General Manager, Ginza HS Clinic (current position) | Director, Ginza HS Clinic (current position) | Graduated from the University of Tokyo, Medical School.
Doctor of Medicine.

The 24th President of the International Society of Hair Restoration Surgery (ISHRS), a Board of Governors of the Asian Association of Hair Restoration Surgeons (AAHRS), a Fellow of the ISHRS, and a Diplomate of the American Board of Hair Restoration Surgery (ABHRS).

He has received many awards for his outstanding achievements in hair transplantation, including “Research Award” and “Special Achievement Award” from the ISHRS, “Mediterranean Award”, “Tiberio Award” and “Caesar Award” from the Italian Society for Hair Science and Restoration, and “Hirayama Award” from the Japan Society of Clinical Hair Restoration.

He is a certified registered physician of the Japan Surgical Society, an Honorary Fellow of cardiovascular surgery of the Japanese Association for Thoracic Surgery, a Fellow of the Japanese Circulation Society, and a Fellow of the Japanese Respiratory Society.

He served as a director of cardiovascular surgery at the Japanese Red Cross Medical Center, and an Assistant Professor at the University of Tokyo, Medical School. He studied at the Hannover Medical School in the Federal Republic of Germany on a scholarship by the Alexander von Humboldt Foundation.

Kuniyoshi Yagyu, MD, FISHRS. He served as the President of the International Society of Hair Restoration Surgery from 2015 to 2016. He is a board member of the Asian Association of Hair Restoration Surgeons. He is a Diplomate of the American Board of Hair Restoration Surgery and a Winner of the ISHRS Research Award in 2010, and ISHRS Poster Award in 2014. He has authored more than 53 research and clinical publications in books and journals. He had been specialized in cardiac surgery for 22 years. He has been practicing hair transplantation for about 20 years in Tokyo, Japan.