Basic Research on Androgenetic Alopecia (AGA) (Vol. 1) Sex Hormone & Hair Loss

Column

Basic Research on Androgenetic Alopecia (AGA) (Vol. 1) Sex Hormone & Hair Loss

Hormonal Changes in the Menstrual Cycle

Female hormones in the serum change cyclically according to the menstrual cycle in women.

Estrogen increases during the follicular phase of the menstrual cycle.

Progesterone increases during the luteal phase.

These changes in hormone levels can affect hair growth.
These hormones belong to the group of steroid hormones.

CYP19 gene encodes Aromatase

Some of estrogens are produced from androgens by the enzyme aromatase in the skin tissue.
Testosterone in the serum is modified to estradiol in the skin tissue by aromatase.

Most of the serum estrogen is produced in the ovaries.
The ovary is rich in aromatase (CYP19).

Aromatase is a complex of cytochrome P450, and it is produced by the CYP-19 gene.

Estrogen

It is still uncertain how estrogen affects hair growth.　

Estrogen slows down the rate of hair growth.

Estrogen antagonists stimulate transmission from the telogen phase to the anagen phase. They induce the telogen phase to the anagen phase in the hair cycle.

1 2 3 4 5 6 7 8 9 10

Kuniyoshi YAGYU, MD

General Manager, Ginza HS Clinic (current position) | Director, Ginza HS Clinic (current position) | Graduated from the University of Tokyo, Medical School.
Doctor of Medicine.

The 24th President of the International Society of Hair Restoration Surgery (ISHRS), a Board of Governors of the Asian Association of Hair Restoration Surgeons (AAHRS), a Fellow of the ISHRS, and a Diplomate of the American Board of Hair Restoration Surgery (ABHRS).

He has received many awards for his outstanding achievements in hair transplantation, including “Research Award” and “Special Achievement Award” from the ISHRS, “Mediterranean Award”, “Tiberio Award” and “Caesar Award” from the Italian Society for Hair Science and Restoration, and “Hirayama Award” from the Japan Society of Clinical Hair Restoration.

He is a certified registered physician of the Japan Surgical Society, an Honorary Fellow of cardiovascular surgery of the Japanese Association for Thoracic Surgery, a Fellow of the Japanese Circulation Society, and a Fellow of the Japanese Respiratory Society.

He served as a director of cardiovascular surgery at the Japanese Red Cross Medical Center, and an Assistant Professor at the University of Tokyo, Medical School. He studied at the Hannover Medical School in the Federal Republic of Germany on a scholarship by the Alexander von Humboldt Foundation.

Kuniyoshi Yagyu, MD, FISHRS. He served as the President of the International Society of Hair Restoration Surgery from 2015 to 2016. He is a board member of the Asian Association of Hair Restoration Surgeons. He is a Diplomate of the American Board of Hair Restoration Surgery and a Winner of the ISHRS Research Award in 2010, and ISHRS Poster Award in 2014. He has authored more than 53 research and clinical publications in books and journals. He had been specialized in cardiac surgery for 22 years. He has been practicing hair transplantation for about 20 years in Tokyo, Japan.